Erstbeschreibung des kaninen leproiden Granuloms in Deutschland: 2 Fallberichte

Zusammenfassung

Bei 2 Hunden wurden im Rahmen der dermatologischen Untersuchung noduläre Hautläsionen im Kopf-/Ohrmuschelbereich nachgewiesen, die mittels histopathologischer, zytologischer und molekularbiologischer Untersuchungen als kanine leproide Granulome charakterisiert werden konnten. Die Erkrankung wird durch nichttuberkulöse, bisher nicht vollständig klassifizierte Mykobakterien verursacht und stellt eine im pazifischen Raum sowie in Nord- und Südamerika dokumentierte Hautläsion dar, die in Deutschland bisher nicht beschrieben wurde. Durch die in beiden Fällen erfolgte Kombination aus chirurgischer und medikamentöser Langzeittherapie (Rifampicin, Clarithromycin, Doxycyclin und lokal Clofazimin) konnten die Granulome entfernt bzw. zur Regression gebracht werden.

Abstract

Using cytology, histopathology, and DNA sequencing the diagnosis of canine leproid granuloma (CLG) was made in 2 dogs. The dogs were presented with nodular skin lesions on the head and pinnae. CLG is caused by nontuberculous mycobacteria that have not yet been finally classified. To date, this disease has been reported in Australia, New Zealand as well as North and South America, however no case reports have been published in Germany until now. In both cases, a combination of surgery and long-term drug administration (rifampicin, clarithromycin, doxycyclin and local application of clofazimin) was chosen and successfully eliminated the granulomas.

Schlüsselwörter

Noduläre Dermatitis - Mykobakterien - DNA-Sequenzierung - Chirurgie

Key words

Nodular dermatitis - mycobacteria - DNA sequencing - surgery

Publication History

Received: 23 October 2019

Accepted: 24 January 2020

Article published online:
18 June 2020

• Literatur

• 1 Charles J, Martin P, Wigney DI. et al. Cytology and histopathology of canine leproid granuloma syndrome. Aust Vet J 1999; 77: 799-803
• 2 Conceição LG, Acha LM, Borges AS. et al. Epidemiology, clinical signs, histopathology and molecular characterization of canine leproid granuloma: a retrospective study of cases from Brazil. Vet Dermatol 2011; 22 (03) 249-256
• 3 Dedola C, Zobba R, Pinna Parpaglia ML. et al. First report of canine leprosy in Europe: molecular and clinical traits. Vet Rec 2014; 174 (05) 120
• 4 Foley JE, Borjesson D, Gross TL. et al. Clinical, Microscopic, and Molecular Aspects of Canine Leproid Granuloma in the United States. Vet Pathol 2002; 39: 234-239
• 5 Gross TL, Ihrke PJ, Walder EJ. et al. Infectious nodular and diffuse granulomatous and pyogranulomatous diseases of the dermis. In: Gross TL, Ihrke PJ, Walder EJ. et al., eds. Skin Diseases of the Dog and Cat: Clinical and Histopathologic Diagnosis. 2nd ed.. Oxford UK: Blackwell Science Ltd; 2005: 272-319
• 6 Hughes MS, James G, Ball N. et al. Identification by 16 S rRNA Gene Analyses of a Potential Novel Mycobacterial Species as an Etiological Agent of Canine Leproid Granuloma Syndrome. J Clin Microbiol 2000; 38 (03) 953-959
• 7 Krug S, Himstedt V, Dorn N. et al. Feline Lepra bei einem 5 Monate alten Kater in Deutschland. Tierarztl Prax Ausg K Kleintiere Heimtiere 2018; 46 (04) 271-275
• 8 Malik R, Love DN, Wigney DI. et al. Mycobacterial nodular granulomas affecting the subcutis and skin of dogs (canine leproidgranuloma syndrome). Aust Vet J 1998; 76 (06) 403-407
• 9 Malik R, Martin P, Wigney D. et al. Treatment of canine leproid granuloma syndrome: preliminary findings in seven dogs. Aust Vet J 2001; 79 (01) 30-36
• 10 Malik R, Smits B, Reppas G. et al. Ulcerated and nonulcerated nontuberculous cutaneous mycobacterial granulomas in cats and dogs. Vet Dermatol 2013; 24 (01) 146-153
• 11 Park H, Jang H, Kim C. et al. Detection and identification of mycobacteria by amplification of the internal transcribed spacer regions with genus- and species-specific PCR primers. J Clin Microbiol 2000; 38 (11) 4080-4085
• 12 Santoro D, Prisco M, Ciaramella P. Cutaneous sterile granulomas/pyogranulomas, leishmaniasis and mycobacterial infections. J Small Anim Pract 2008; 49 (11) 552-561
• 13 Sen Gupta R, Hillemann D, Kubica T. et al. HOPE-fixation enables improved PCR-based detection and differentiation of Mycobacterium tuberculosis complex in paraffin-embedded tissues. Pathol Res Pract 2003; 199 (09) 619-623
• 14 Smith RIE. Canine skin tuberculosis. Rhod Vet J 1973; 3: 63-64
• 15 Smits B, Willis R, Malik R. et al. Case clusters of leproid granulomas in foxhounds in New Zealand and Australia. Vet Dermatol 2012; 23 (06) 465-488